Skin Cancer in Albinos' Patients

Albinism is an inheritable disorder that affects the melanin production due to the absence or defect in tyrosinase enzyme which converts tyrosine to dioxyphenylalanine (the precursor of melanin) . 1 Mutations in tyrosinase (TYR) gene (11q14-q21), resulting in impaired tyrosinase activity, are by far the most common and affect up to 50% of cases worldwide . 3 This leads to the absence or reduction in melanin produced in the melanocytes which affect the skin, eyes, and hair