医学
内科学
乳腺癌
血小板
平均血小板体积
红细胞分布宽度
肿瘤科
胃肠病学
癌症
接收机工作特性
中性粒细胞与淋巴细胞比率
单变量分析
作者
Hideya Takeuchi,Daiki Noda,Miyuki Abe,Kentaro Anami,Michiyo Miyawaki,Atsushi Osoegawa,Kenji Sugio
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2020-07-01
卷期号:40 (7): 3947-3952
被引量:1
标识
DOI:10.21873/anticanres.14386
摘要
AIM This study aimed to evaluate plateletcrit (PCT) and platelet distribution width-to-PCT ratio (PDW/PCT) as potential prognostic biomarkers in patients with breast cancer. PATIENTS AND METHODS Information of 337 patients was retrospectively reviewed. The Cox regression proportional hazards model was used to evaluate the prognostic value of PCT and PDW/PCT compared to the platelet distribution width-to-platelet count ratio (PDW/P) and red cell distribution width-to-platelet count ratio (RDW/P). RESULTS Large tumor size (p<0.01), lymph node involvement, and increased PDW/P, RDW/P, and PDW/PCT (p<0.05) were significantly associated with inferior disease-free survival (DFS) according to the univariate analysis. The multivariate analysis showed that large tumor size (p<0.01) and increased PDW/PCT (p<0.05) were significant prognostic factors for poor DFS. CONCLUSION To our knowledge, this is the first report to show that PDW/PCT is a significant prognostic factor for patients with breast cancer. Therefore, it might be an attractive biomarker providing additional prognostic information for these patients.
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