脂肪甘油三酯脂肪酶
脂质体
安普克
脂质代谢
细胞生物学
脂肪组织
脂类学
脂质氧化
磷脂酶A2
蛋白激酶A
磷脂酶
脂滴
生物化学
脂质信号
生物
鞘脂
鞘磷脂
磷脂
激酶
酶
脂解
抗氧化剂
作者
Sebastian Schmeisser,Shaolin Li,Bertrand Bouchard,Matthieu Ruiz,Christine Des Rosiers,Richard Roy
出处
期刊:Cell Reports
[Elsevier]
日期:2019-12-24
卷期号:29 (13): 4540-4552.e8
被引量:17
标识
DOI:10.1016/j.celrep.2019.11.090
摘要
A growing body of evidence suggests that changes in fat metabolism may have a significant effect on lifespan. Accumulation of lipid deposits in non-adipose tissue appears to be critical for age-related pathologies and may also contribute to the aging process itself. We established a model of lipid storage in muscle cells of C. elegans to reveal a mechanism that promotes longevity non-cell-autonomously. Here, we describe how muscle-specific activation of adipose triglyceride lipase (ATGL) and the phospholipase A2 (PLA2) ortholog IPLA-7 collectively affect inter-tissular communication and systemic adaptation that requires the activity of AMP-dependent protein kinase (AMPK) and a highly conserved nuclear receptor outside of the muscle. Our data suggest that muscle-specific bioactive lipid signals, or "lipokines," are generated following triglyceride breakdown and that these signals impinge on a complex network of genes that modify the global lipidome, consequently extending the lifespan.
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