肿胀 的
自愈水凝胶
热重分析
热稳定性
化学工程
生物相容性
纤维素
溶解度
药物输送
单体
膨胀能力
高分子化学
毒品携带者
化学
水解
核化学
聚合物
材料科学
有机化学
工程类
作者
Xinxin Yang,Zhaoshuang Li,He Liu,Lina Ma,Xujuan Huang,Zhaosheng Cai,Xu Xu,Shibin Shang,Zhanqian Song
标识
DOI:10.1016/j.ijbiomac.2019.12.019
摘要
N-vinylcaprolactam (NVCL) is a temperature-responsive monomer, which is widely used for preparing responsive hydrogels. However, poor water solubility of NVCL necessitates the use of emulsifiers for better dispersion. Hydrolyzed epoxy soybean oil-grafted hydroxyethyl cellulose (H-ESO-HEC) polymeric emulsifier has excellent emulsifying properties, and the carboxyl groups afford pH-responsiveness to the hydrogels. A novel temperature- and pH-responsive cellulose-based hydrogel was prepared by combining NVCL and H-ESO-HEC. The hydrogel morphology, thermal stability, and swelling capacity were characterized, and it was also used as a dual-responsive drug preservative carrier. Scanning electron microscopy and thermogravimetric analysis confirmed the porous structure and good thermal stability, respectively, of the hydrogel. The hydrogel displayed a temperature- and pH-dependent swelling behavior and improved swelling capacity. The swelling behavior agreed well with the Korsmeyer-Peppas model and Schott's second-order kinetic model. The dual-responsive hydrogel has significant potential in the drug delivery systems owing to its biocompatibility and temperature and pH sensitivity.
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