适应(眼睛)
细胞适应
代谢适应
压力(语言学)
计算生物学
生物
神经科学
新陈代谢
生物化学
基因
语言学
哲学
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-11-12
卷期号:370 (6518): 805.2-805
标识
DOI:10.1126/science.370.6518.805-b
摘要
Stress Responses
Cells respond to environmental stress by down-regulating general protein synthesis and inducing selective expression of proteins required for survival. However, the mechanisms controlling this selective messenger RNA (mRNA) translation response remain poorly understood. Lamper et al. report that the noncanonical 5′ cap-binding protein subunit eIF3d is activated upon metabolic stress in mammalian cells to reprogram cellular mRNA translation. eIF3d is activated by a switch in phosphorylation status at sites near the cap-binding pocket and enables cells to express the proteins required for the regulation of metabolism and survival during stresses, including glucose starvation. This work reveals how eIF3d-dependent, noncanonical cap-dependent translation controls the cellular adaptation to stress.
Science , this issue p. [853][1]
[1]: /lookup/doi/10.1126/science.abb0993
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