Research progress of idiopathic membranous nephropathy associated antigen phospholipase A2 receptor and thrombospondin type-1 domain containing 7A

Idiopathic membranous nephropathy(IMN) is one of the main pathology of nephrotic syndrome, and has a rising trend year by year.In recent years that IMN is organ specific autoimmune disease.Phospholipase A2 receptor(PLA2R) and thrombospondin type-1 domain containing 7A(THSD7A) are the two main antigens of IMN, which could be used to distinguish the IMN and secondary membranous nephropathy.The anti-PLA2R antibody and anti-THSD7A antibody are associated with diagnosis, severity and activity of the disease.The antibody titer and its change could be used to help deciding the beginning of therapy and the therapitive courses. Key words: Idiopathic membranous nephropathy; Phospholipase A2 receptor; Thrombospondin Type-1 Domain containing 7A