免疫
FOXP3型
信号转导
免疫系统
免疫学
细胞生物学
癌症研究
生物
细胞因子
白细胞介素9
白细胞介素
作者
Yayi He,Dong Lin,Yejin Cao,Yujing Bi,Guangwei Liu
标识
DOI:10.1007/978-3-030-38315-2_3
摘要
T cells can be categorized into functionally diverse subpopulations, which include Th1, Th2, Th9, Th17, Th22, and Tfh cells and Foxp3+ Tregs, based on their role in maintaining normal immune homeostasis and affecting pathological immune-associated diseases. Among these subpopulations, Th9 cells are relatively new, and less is known about their signaling and effects on tumor immunity. Recently, some studies have focused on regulation of the IL-9/IL-9R signaling pathway and Th9 cell differentiation and their roles in tumor environments. Herein, we summarize recent progress in understanding the regulatory signaling of IL-9 and Th9 cells and their critical roles and mechanisms in antitumor immunity.
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