Function of transcription factor PU.1 in haematopoietic differentiation

PU.1 is a member of the Ets transcription family and is predominantly expressed in haematopoietic cells such as myeloid cells and B lymphoid cells. PU.1 regulates the expression of a number of myeloid gene and the haematopoietic differentiation. The disruption of PU.1 function is involved in acute myeloid leukemia.