内质网
未折叠蛋白反应
生物
秀丽隐杆线虫
细胞生物学
家蚕
超氧化物歧化酶
自噬
氧化应激
生物化学
基因
细胞凋亡
作者
Jiangbo Song,Min Chen,Zhiquan Li,Jianfei Zhang,Hai Hu,Xiaoling Tong,Fangyin Dai
出处
期刊:Aging and Disease
[Aging and Disease]
日期:2019-12-01
卷期号:10 (6): 1187-1187
被引量:12
标识
DOI:10.14336/ad.2019.0515
摘要
The traditional Chinese medicine Astragalus polysaccharide (APS) has been widely used to improve glucose homeostasis and immunoregulator properties. In recent years, it has also been shown to extend the lifespan of Caenorhabditis elegans; however, the underlying molecular mechanisms are not fully understood. Here, our study shows that APS could significantly extend adult stage, mean, and maximum lifespan of the silkworm, Bombyx mori and increase body weight without affecting food intake and fecundity. Meanwhile, the activities of glutathione S-transferase and superoxide dismutase are significantly enhanced, and the reaction oxygen species content is reduced concomitantly. Moreover, the activity of lysozyme is increased dramatically. In addition, APS rescues the shortened lifespan by Bacillus thuringiensis infection in silkworm. Furthermore, the transcription of the crucial genes involved in endoplasmic reticulum stress is upregulated upon the endoplasmic reticulum stress stimulation. APS also significantly ameliorates endoplasmic reticulum stress in silkworm cell line and in vivo. Together, the results of this study indicate that APS can prolong the silkworm lifespan by mitigating endoplasmic reticulum stress. This study improves our understanding of the molecular mechanism of APS-induced lifespan extension and highlights the importance of the silkworm as an experimental animal for evaluating the effects and revealing the mechanisms in lifespan extension of traditional Chinese medicine.
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