炎症性肠病
溃疡性结肠炎
炎症
血管生成
免疫系统
医学
病理生理学
克罗恩病
疾病
免疫学
炎症性肠病
结肠炎
病理
癌症研究
作者
Ossama A. Hatoum,Jan Heidemann,David G. Binion
标识
DOI:10.1196/annals.1326.003
摘要
Abstract: Chronic inflammation is a complex biologic process which involves immune as well as non‐immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.
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