伤口愈合
纤维化
转化生长因子
调解人
背景(考古学)
转化生长因子β
基因亚型
细胞外基质
成纤维细胞
肌成纤维细胞
医学
转化生长因子β信号通路
纤维连接蛋白
病理
SMAD公司
转化生长因子-α
生长因子
化学
细胞生物学
免疫学
内科学
生物
基因
古生物学
生物化学
作者
Michael K. Lichtman,Marta Otero-Viñas,Vincent Falanga
摘要
Scar formation, with persistent alteration of the normal tissue structure, is an undesirable and significant result of both wound healing and fibrosing disorders. There are few strategies to prevent or to treat scarring. The transforming growth factor beta (TGF-β) superfamily is an important mediator of tissue repair. Each TGF-β isoform may exert a different effect on wound healing, which may be context-dependent. In particular, TGF-β1 may mediate fibrosis in adults' wounds, while TGF-β3 may promote scarless healing in the fetus and reduced scarring in adults. Thus, TGF-β3 may offer a scar-reducing therapy for acute and chronic wounds and fibrosing disorders.
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