ENETS Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms

New epidemiological data come from a study performed in Argentina [2] , showing that g-NENs and d-NENs represent 6.9 and 2.0% of all digestive NENs, respectively.These data are similar to the SEER data, where g-NENs were found to represent 8.7% of all enteric NENs [3] , and quite similar to a recent prospective Austrian study by Niederle et al. [4] , where g-NENs represented 5.6% of all digestive NENs.The proportions of g-NENs with respect to the overall NEN rates do vary, however; g-NENs represented 23% of all NENs in the Austrian study compared to 6% in the SEER data, 5% in a Canadian study (Ontario) and 7.4% in a Taiwanese study [4][5][6][7] .These differences underline the need for multicenter prospective studies with long-term analysis to better describe the European epidemiology of these tumors.