线粒体通透性转换孔
信号转导
ATP合酶
病理生理学
线粒体
细胞生物学
化学
三磷酸腺苷
生物物理学
生物
生物化学
酶
内分泌学
细胞凋亡
程序性细胞死亡
作者
Paolo Bernardi,Andrea Rasola,Michael Forte,Giovanna Lippe
标识
DOI:10.1152/physrev.00001.2015
摘要
The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of putative protein components that have been tested by genetic analysis. The discovery that under conditions of oxidative stress the F-ATP synthases of mammals, yeast, and Drosophila can be turned into Ca 2+ -dependent channels, whose electrophysiological properties match those of the corresponding PTPs, opens new perspectives to the field. We discuss structural and functional features of F-ATP synthases that may provide clues to its transition from an energy-conserving into an energy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
科研通智能强力驱动
Strongly Powered by AbleSci AI