Wnt信号通路
骨形态发生蛋白
Notch信号通路
生物
信号转导
淋巴系统
细胞生物学
神经科学
免疫学
遗传学
基因
作者
Amaya García de Vinuesa,Salim Abdelilah‐Seyfried,Petra Knaus,An Zwijsen,Sabine Bailly
标识
DOI:10.1016/j.cytogfr.2015.12.005
摘要
The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology.
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