菲格拉斯汀
医学
中性粒细胞减少症
化疗
卡铂
药代动力学
毒性
内科学
聚乙二醇非格司亭
胃肠病学
中性粒细胞绝对计数
粒细胞集落刺激因子
药效学
外科
麻醉
顺铂
作者
Eileen Johnston,Jeffrey Crawford,Susan Blackwell,Toni Bjurstrom,Pamela Lockbaum,Lorin Roskos,Bingbing Yang,Sheila Gardner,Mary Ann Miller‐Messana,Debra Shoemaker,Jennifer Garst,G Schwab
标识
DOI：10.1200/jco.2000.18.13.2522
摘要
A single dose of SD/01 increases the serum concentration of SD/01 for several days in a dose-dependent fashion and is not associated with significant toxicity. The effects of SD/01 on ANC and CD34(+) cell mobilization are comparable or greater than those achieved with daily filgrastim. The self-regulation of this molecule provides a potential therapeutic advantage in a variety of clinical settings associated with neutropenia.
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