血管生成
细胞生物学
线粒体
线粒体生物发生
生物
生物发生
平衡
神经科学
基因
癌症研究
遗传学
作者
Sergio Caja,José Antonio Enríquez
出处
期刊:Redox biology
[Elsevier]
日期:2017-08-01
卷期号:12: 821-827
被引量:102
标识
DOI:10.1016/j.redox.2017.04.021
摘要
The involvement of angiogenesis in disease and its potential as a therapeutic target have been firmly established over recent decades. Endothelial cells (ECs) are central elements in vessel homeostasis and regulate the passage of material and cells into and out of the bloodstream. EC proliferation and migration are modified by alterations to mitochondrial biogenesis and dynamics resulting from several signals and environmental cues, such as oxygen, hemodynamics, and nutrients. As intermediary signals, mitochondrial ROS are released as important downstream modulators of the expression of angiogenesis-related genes. In this review, we discuss the physiological actions of these signals and aberrant responses during vascular disorders.
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