Total of 40 Malignant Lesions were Randomized into the two arms 19patients(total 22) in CCRT+ gefitinib arm have shown complete response in comparison to 11patients(total 18) in CCRT arm Conclusion: EGFR status evaluation in premalignant can be used as a screening tool for detection of transformation into malignant lesions.We can prevent this transformation by EGFR inhibitors.In malignant lesions it can be really important for the role of EGFR inhibitors .Eg Gefitinib has shown good results when combined with the conventional CCRT.