Autoimmune hemolytic anemia (Hb 4.1g/dl, reticurocyte count 18.1%) developed in a 42-year-old woman who took any drug before admission. The supernatant of her red cell's eluate prepared from the procedure of adsorption technique with Jk (a- b-) normal red cells, contained antibody with anti Jka specificity. Her antibody was confirmed to have the characterization of IgG1.