内分泌学
脂肪因子
肠道菌群
生物
新陈代谢
信号转导
受体
激素
细胞生物学
脂质代谢
内科学
肥胖
瘦素
免疫学
生物化学
医学
作者
Stephen Gaudino,Hanchun Huang,Makheni Jean-Pierre,Preet Joshi,Michael Beaupre,Cody Kempen,Hoi Tong Wong,Perikala V. Kumar
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2021-10-15
卷期号:207 (8): 1959-1963
被引量:1
标识
DOI:10.4049/jimmunol.2000986
摘要
Previous studies indicate that IL-17A plays an important role in mediating the intestinal microbiota and systemic metabolic functions. However, it is not known where IL-17RA signaling occurs to mediate these effects. To investigate this question, we used intestinal epithelial-specific (Il17raΔIEC ) and liver-specific (Il17raΔLiver ) IL-17RA knockout mice as well as littermate control mice. Our results indicate that intestinal IL-17RA signaling helps mediate systemic metabolic functions upon exposure to prolonged high-fat diet. Il17raΔIEC mice display impaired glucose metabolism, altered hormone and adipokine levels, increased visceral adiposity, and greater hepatic lipid deposition when compared with their littermate controls. We show that IL-17RA-driven changes in microbiota composition are responsible for regulating systemic glucose metabolism. Altogether, our data elucidate the importance of intestinal IL-17RA signaling in regulating high-fat diet-mediated systemic glucose and lipid metabolism.
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