PERBANDINGAN EFEKTIVITAS DESLORATADIN DAN LORATADINDALAM MENURUNKAN SKOR GEJALA HIDUNG TOTAL DAN KADARINTERLEUKIN 4 SEKRET HIDUNG PADA PENDERITA RINITIS ALERGI

Allergic rhinitis (AR) is a common inflammation disease mediated by \nImmunoglobulin E (IgE) after exposure to allergen in the nasal mucosa. Allergic rhinitis \nsymptom severity ratings assessment are determined by total nasal symptom score (TNSS) \nand clinical manifestations are influenced by interleukin-4 (IL-4). Loratadine is a second \ngeneration antihistamine showed less effective at removing all of symptoms. Desloratadine \nwhich is a derivative of loratadine are considered to eliminate the overall symptoms of AR \nand reduce levels of IL-4 nasal secretion. The aim of this study was to assess the effectiveness \nof desloratadine and loratadine in decreasing TNSS and levels of IL-4 nasal secretions on AR \npatients. \nStudy design : experimental study with a double blind randomized clinical trial (RCT). \nMethods : Allergic rhinitis patients who meet the inclusion dan exclusion criteria were \nexamined in Allergy Immunology division of ORL-HNS OPD followed with TNSS \nassessment and levels of nasal secretion by nasal lavage method. Desloratadine or loratadine \ntherapy had been taken for 14 days as the samples. Evaluating patients for TNSS and nasal \nlavage become a major sampling for measuring IL-4 nasal secretion level on day 15 th. \nResult : There were 24 samples consist of 12 samples from desloratadine group and 12 \nsamples from loratadine group. Decreasing of TNSS in desloratadine group and loratadine \ngroup was 7.67 (SD 1.77) and 2.42 (SD 1.62) with p=0,000. Independent t-test showed that \ncomparison of decreasing of TNSS between two groups was significantly different (p<0.05). \nDecreasing of IL-4 nasal secretion level on desloratadine group and loratadine group \nwas 22.54 (SD 48.78) pg/ml and 4.68 (SD 13.90) pg/ml with p = 0.236. Independent ttest \nshowed that comparison of decreasing of IL-4 nasal secretion level between desloratadine \ngroup and loratadine group was not significantly different (p>0.05). \nConclusion : This study shows that the TNSS was decrease more in desloratadine compared \nto loratadine, but there is no differences from the levels of IL-4 nasal secretions. \nDesloratadine is more effective to reduce TNSS compared to loratadine in patients with AR, \nbut the efficacy in both of group are same