核酸
鸟苷
功能(生物学)
G-四倍体
计算生物学
生物物理学
动力学(音乐)
分子动力学
化学
核糖核酸
DNA
纳米技术
生物
物理
基因
细胞生物学
生物化学
计算化学
声学
材料科学
作者
Robert W. Harkness,Anthony Mittermaier
标识
DOI:10.1016/j.bbapap.2017.06.012
摘要
G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to their conformational dynamics, despite the fact that many biological GQ sequences populate multiple structures of similar free energies, leading to an ensemble of exchanging conformations. The impact of these dynamics on biological function is currently not well understood. Recently, structural dynamics have been demonstrated to entropically stabilize GQ ensembles, potentially modulating gene expression. Transient, low-populated states in GQ ensembles may additionally regulate nucleic acid interactions and function. This review will underscore the interplay of GQ dynamics and biological function, focusing on several dynamic processes for biological GQs and the characterization of GQ dynamics by nuclear magnetic resonance (NMR) spectroscopy in conjunction with other biophysical techniques. This article is part of a Special Issue entitled: Biophysics in Canada, edited by Lewis Kay, John Baenziger, Albert Berghuis and Peter Tieleman.
科研通智能强力驱动
Strongly Powered by AbleSci AI