变性(医学)
细胞生物学
化学
软骨
细胞外基质
软骨细胞
下调和上调
阿格里坎
骨关节炎
解剖
关节软骨
生物
生物化学
基因
病理
医学
替代医学
作者
Liang Xiao,Baiyang Ding,Shujuan Xu,Jianming Gao,Bijing Yang,Jing Wang,Haixia Xu
摘要
Abstract Excessive mechanical tension can lead to the degeneration of endplate chondrocytes. The presence of tension‐sensitive circRNA_0058097 molecules has been detected in human endplate chondrocytes, where it was found to be a potential competing endogenous RNA. Indeed, inhibiting the expression of circRNA_0058097 effectively enhanced the stress resistance of endplate chondrocytes, suggesting that it may be an important trigger point for the degeneration of endplate cartilage. Through a series of experiments, we reveal that circRNA_0058097 can upregulate the expression of downstream target gene histone deacetylase 4 by sponge adsorption of miR‐365a‐5p, which promoted morphological changes of endplate chondrocytes, and increased extracellular matrix degradation and degeneration of endplate cartilage. Therefore, circRNA_0058097 may provide a new way to prevent and treat endplate cartilage degeneration.
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