Application of Hantzsch Ester and Meyer Nitrile in Radical Alkynylation Reactions

The first example of constructing a C_sp3-C_sp bond with substituted Hantzsch ester and Meyer nitrile is reported. When benziodoxole-activated alkyne was applied as the alkynyl donor, products containing C_sp3-C_sp bonds involving primary, secondary, and tertiary carbon centers were achieved in up to 97% yields. K₂S₂O₈ was the optimum radical initiator in this reaction.