微泡
肿瘤微环境
重编程
生物
转移
外体
癌变
基质
肿瘤进展
小RNA
利基
癌症研究
癌症
免疫学
肿瘤细胞
细胞
遗传学
基因
免疫组织化学
生态学
作者
Kaity Tung,Marc S. Ernstoff,Cheryl Allen,Shin La Shu
出处
期刊:Journal of immunological sciences
[Sciaccess Publishers LLC]
日期:2019-01-01
卷期号:3 (1): 4-8
被引量:42
标识
DOI:10.29245/2578-3009/2019/1.1165
摘要
Tumor-derived exosomes (TEX) are important intercellular messengers that contribute to tumorigenesis and metastasis through a variety of mechanisms such as immunosuppression and metabolic reprogramming that generate a pre-metastatic niche favorable to tumor progression. Our lab has contributed further to the understanding of the miRNA payloads in TEX by demonstrating that human melanoma-derived exosome (HMEX) associated miRNAs contribute to the metabolic reprogramming of normal stroma. This mini-review highlights the role of TEX in the tumor microenvironment (TME) and the hypothesis that exosomes may also generate a host-tumor "macroenvironment" beyond the TME through their miRNA and protein payloads, so to speak "fertilizing the soil for cancer seeding."
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