舒尼替尼
血管生成
光热治疗
脂质体
体内
癌症研究
药物输送
化学
体外
药理学
医学
癌症
材料科学
生物
纳米技术
生物化学
内科学
生物技术
有机化学
作者
Xue Yang,Huipeng Li,Chenggen Qian,Yuxin Guo,Chenzi Li,Fang Gao,Ying Yang,Kaikai Wang,David Oupický,Minjie Sun
标识
DOI:10.1016/j.nano.2018.06.011
摘要
Tumor angiogenesis is a key step in the process of tumor development, and antitumor angiogenesis has a profound influence on tumor growth. Herein we report a dual-function drug delivery system comprising a Near-infrared (NIR) dye and an anti-angiogenic drug within liposomes (Lip-IR780-Sunitinib) for enhanced antitumor therapy. The hydrophobic NIR dye IR780 was loaded into the liposome phospholipid bilayer, and the bilayer would be disrupted by laser irradiation so that anti-angiogenic drug sunitinib release would be activated remotely at the tumor site. The released hydrophilic sunitinib could potentially target multiple VEGF receptors on the tumor endothelial cell surface to inhibit angiogenesis. Meanwhile, IR780-loaded liposomes kill the cancer cells by photothermal therapy. Lip-IR780-Sunitinib exhibited enhanced anti-tumor and anti-angiogenic effects in vitro and in vivo. This system facilitates easy and controlled release of cargos to achieve anti-tumor angiogenesis and photothermal therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI