葡萄糖激酶
2型糖尿病
医学
葡萄糖稳态
内分泌学
内科学
变构调节
糖尿病
碳水化合物代谢
调节器
低血糖
糖原
2型糖尿病
生物化学
化学
受体
胰岛素抵抗
基因
作者
Aditi Kaushik,Manish Kaushik
出处
期刊:Current Diabetes Reviews
[Bentham Science]
日期:2019-04-01
卷期号:15 (3): 205-212
被引量:5
标识
DOI:10.2174/1573399814666180724100749
摘要
<P>Introduction: The impairment of glucose metabolism leads to hyperglycemia and type-2 diabetes mellitus. Glucokinase enzyme is the key regulator of glucose homeostasis that catalyzes the conversion of glucose to glucose-6-phosphate in liver and pancreatic cells. In hepatocytes, GK controls the glucose uptake and glycogen synthesis. The action of liver GK is controlled by Glucokinase Regulatory Protein (GKRP) partially. In fasting conditions the GKRP binds with GK and inactivate it from carbohydrate metabolism and serve as new target for treatment of diabetes mellitus. However, the GK activators as potential antidiabetic agents but results in increased risks of hypoglycemia. Conclusion: The allosteric inhibitors of the GK-GKRP interaction are coming as alternative agents that can mitigate the risk associated with GK activators. This review discusses the recent advances and current status of potential molecules targeted to GK activators and GK-GKRP disrupters.</P>
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