Design and Development of an Additive Manufacturing Technology Platform for Melt Electrospinning Writing - A Systems Engineering Approach

This thesis establishes an additive biomanufacturing technology platform for melt electrowriting. It has been hypothesised that applying systems engineering methodologies assists in developing control, reproducibility, and scale. The implementation of automated monitoring and parameter control helped to generate large data to identify the optimum settings. A conclusion is drawn between the geometry of a fibre and the quality of morphology, assessing robustness and reproducibility. Additionally, contemporary achievable scaffold fabrication heights of 2 mm to 7 mm is achieved and the influence of gravity is evaluated. The resulting technologies are utilised to design and develop a high-throughput printer.