One-Pot Construction of CF 3 -Tetrahydroindeno[1,2- b ]pyrrol-4(1 H )-ones from 2-[3-(Trifluoromethyl)but-3-en-1-yn-1-yl]benzaldehyde Derivatives and Primary Aliphatic Amines

This study successfully developed an efficient one-pot NHKM (nucleophilic addition, hydrolysis, Knoevenagel condensation, and Michael addition) reaction for synthesizing CF₃-tetrahydroindeno[1,2-b]pyrrol-4(1H)-one from 2-[3-(trifluoromethyl)but-3-en-1-yn-1-yl]benzaldehyde derivatives and primary aliphatic amines. The process constructs two rings and three bonds with 100% atom economy and high step-efficiency. Moreover, the reaction exhibits broad substrate compatibility and mild conditions, offering a valuable synthetic protocol for bioactive molecules containing the CF₃-tetrahydroindeno[1,2-b]pyrrol-4(1H)-one scaffold.