Redox Modification of Ryanodine Receptors in Cardiac Arrhythmia and Failure: A Potential Therapeutic Target

This chapter contains sections titled: Introduction Activation and Deactivation of Ryanodine Receptors During Normal Excitation-Contraction Coupling Defective Ryanodine Receptor Function is Linked to Proarrhythmic Delayed Afterdepolarizations and Calcium Alternans Genetic and Acquired Defects in Ryanodine Receptors Effects of Thiol-Modifying Agents on Ryanodine Receptors Reactive Oxygen Species Production and Oxidative Stress in Cardiac Disease Redox Modification of Ryanodine Receptors in Cardiac Arrhythmia and Heart Failure Therapeutic Potential of Normalizing Ryanodine Receptor Function References