化学
对映体
立体化学
残留物(化学)
生物碱
蜘蛛精子
醋酸
有机化学
吲哚试验
作者
Carl Djerassi,A. A. P. G. Archer,Thomas J. George,B. Gilbert,L. D. Antonaccio
出处
期刊:Tetrahedron
[Elsevier]
日期:1961-01-01
卷期号:16 (1-4): 212-223
被引量:19
标识
DOI:10.1016/0040-4020(61)80073-2
摘要
The isolation and structure elucidation of three new Aspidosperma alkaloids is reported. Cylindrocarpine (II) and cylindrocarpidine (XI) are noteworthy in that they represent analogs of aspidospermine (I) in which the latter's angular ethyl group has been replaced by an angular acetic acid methyl ester function. Furthermore, cylindrocarpine (II) represents the first naturally occurring dihydroindole with a N-cinnamoyl residue. Pyrifolidine (XII) has been shown to be the antipode of O-methylaspidocarpine (XV) and thus bears an enantiomeric relationship at all four asymmetric centers to (-)-aspidospermine (I). Attention is drawn to the possible biogenetic implications of this observation.
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