嗜铬细胞
血清素
免疫系统
炎症
5-羟色胺受体
血小板
生物
肠-脑轴
神经科学
免疫学
受体
生物化学
作者
Suhrid Banskota,Waliul I. Khan
出处
期刊:Current Opinion in Endocrinology, Diabetes and Obesity
[Ovid Technologies (Wolters Kluwer)]
日期:2022-01-19
卷期号:29 (2): 177-182
被引量:13
标识
DOI:10.1097/med.0000000000000713
摘要
Purpose of review To shed light on the recently uncovered diverse role of serotonin (5-hydroxytryptamine; 5-HT) in the regulation of immune functions, inflammation, metabolism, and gut–brain axis. Recent findings Peripheral 5-HT which accounts for approximately 95% of the total is largely synthesized in the gut by enterochromaffin cells. Enterochromaffin cells release 5-HT in response to various stimuli including microbial products. Released 5-HT influences secretomotor, sensory and immune functions as well as inflammatory processes in the gut. 5-HT released from enterochromaffin cells enters circulation and is taken up and concentrated in platelets. 5-HT released from the activated platelets interacts with different organs to alter their metabolic activity. 5-HT also serves as a link in the gut–brain axis. Summary Emerging evidence regarding the role of peripheral 5-HT in the regulation of various physiological and pathophysiological conditions opens up new targets for researchers to explore and for clinicians to treat and manage different diseases associated with the altered 5-HT signalling.
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