[Current Status and Progress of Thermal Ablation Combined with Immunotherapy for Lung Tumors].

Recent studies have shown that tumor immune microenvironment is closely related to tumor progression, metastasis, recurrence and response to treatment. Some immunotherapies also offer hope for cancer patients. However, the efficacy of tumor immunotherapy is uncertain and has some side effects. In order to enhance its efficacy, tumor immunotherapy combined with tumor thermal ablation has been studied. Thermal ablation has the advantages of minimally invasive, rapid recovery, safety, fewer complications, conformation, reliable effect, repeatable, low cost, and has become the fourth tumor treatment measure after surgery, radiotherapy, and drug therapy. It can directly kill tumor cells and modulate the immune system through a variety of mechanisms, although the corresponding mechanisms are not well understood, but combined tumor immunotherapy has been proposed to treat several solid malignancies. In this review, the current status and progress of thermal ablation combined with immunotherapy for lung tumor were reviewed, and further studies on the efficacy and safety of thermal ablation combined with immunotherapy were expected. .【中文题目：肺部肿瘤热消融联合免疫治疗现状与进展】 【中文摘要：近来的研究表明，肿瘤免疫微环境与肿瘤的进展、转移、复发以及对治疗的反应密切相关；一些免疫治疗也给肿瘤患者带来了希望。然而，肿瘤免疫治疗存在疗效的不确定性和一定的副作用，为了增强其疗效，肿瘤免疫治疗联合肿瘤热消融的研究开始出现。肿瘤热消融具有微创、恢复快、安全、并发症少、适形、效果可靠、可重复、费用低等优点，现已成为继手术、放疗、药物治疗之后的肿瘤第四大治疗手段。它可以直接杀死肿瘤细胞并通过多种机制调节免疫系统，虽然相应的机制尚不清楚，但是联合肿瘤免疫治疗已被建议用于治疗几种实体恶性肿瘤。本文对肿瘤免疫治疗、肿瘤热消融、肺部肿瘤热消融联合肿瘤免疫的现状和进展进行了简要综述，并期待对肿瘤热消融联合肿瘤免疫的有效性和安全性的进一步研究。 】 【中文关键词：肺肿瘤；热消融；免疫治疗】.