Depression reduces neural correlates of reward salience with increasing effort over the course of the progressive ratio task

Depressive disorders have been associated with altered effort-cost decision making (ECDM) in behavioral investigations, such as a decreased willingness to expend effort for reward attainment. However, little is known about neural mechanisms implicated in altered ECDM.The study investigates neural correlates of reward attainment during a progressive ratio task in participants with a current depressive disorder (n = 65) and never-depressed healthy individuals (n = 44). On each trial, participants completed an increasing number of button presses to attain a fixed monetary reward, indicated by an auditory reward signal. Participants could decide to quit the task anytime (breakpoint). EEG was recorded during the task and P300 amplitudes were examined in response to the auditory signal of reward attainment.There was no difference in breakpoint, as both groups completed comparable numbers of button presses. In contrast, results from mixed-effects models of trial-level ERP responses indicated depression-related effects on P300 amplitudes over the course of the task. Generally, the reward-locked P300 increased with ascending effort expenditure; however, compared to healthy participants, individuals with current depression were characterized by an attenuated trajectory of the reward-locked P300, pointing towards decreased reactivity to reward attainment with increasing effort.Sample size and reward magnitude were possibly not large enough to detect differences in breakpoint.The results of the current study demonstrate that the investigation of reward-related P300 trajectory may represent an informative novel addition to the progressive ratio task, which could help shed light on depression-related alterations in motivation and ECDM.