镍
试剂
芳基
对映选择合成
醇盐
化学
催化作用
锌
分子间力
组合化学
基质(水族馆)
分子
金属
有机化学
地质学
烷基
海洋学
作者
Ziqi Zhu,Jieshuai Xiao,Mingjie Li,Zhuangzhi Shi
标识
DOI:10.1002/anie.202201370
摘要
Enantioenriched alcohols comprise much of the framework of organic molecules. Here, we first report that chiral nickel complexes can catalyze the intermolecular enantioselective addition of aryl iodides across aldehydes to provide diverse optically active secondary alcohols using zinc metal as the reducing agent. This method shows a broad substrate scope under mild reaction conditions and precludes the traditional strategy through the pre-generation of organometallic reagents. Mechanistic studies indicate that an in situ formed arylnickel, instead of an arylzinc, adds efficiently to aldehydes, forming a new C-C bond and a chiral nickel alkoxide that may be turned over by zinc powder.
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