Synergistic Dual Amine/Transition Metal Catalysis: Recent Advances

Abstract Dual Catalysis has enabled a plethora of novel unconventional transformations that would have been unattainable by either catalyst alone. The enormous potential of dual catalysis hinges on the synergistic activation of two substrates in discrete catalytic cycles without interfering with one another. The last decade had witnessed diverse dual‐catalyst systems focusing mainly on the combination of transition metal catalysis with either one of Lewis acid catalysis, photoredox catalysis, biocatalysis or organocatalysis (i. e., Lewis bases, Brønsted acids and NHC catalysts). In this setting, the scientific community has greatly embraced the integration of amine catalysts with transition metal catalysts. This Review comprehends the reported examples from the past decade on dual amine/transition metal catalysis and discuss the various activation modes for the functionalisation of carbonyl compounds.