明胶
伤口愈合
再生(生物学)
自愈水凝胶
皮肤修复
移植
人造皮肤
生物相容性材料
生物医学工程
材料科学
化学
医学
细胞生物学
外科
高分子化学
生物
生物化学
作者
Jianghong Huang,Xiaofei Lei,Zhiwang Huang,Zhibin Rong,Haihang Li,Yixin Xie,Duan Li,Jianyi Xiong,Daping Wang,Shishu Zhu,Yujie Liang,Jianhao Wang,Jiang Xia
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2022-02-24
卷期号:8 (2): 517-517
被引量:12
标识
DOI:10.18063/ijb.v8i2.517
摘要
Artificial skins are biomaterials that can replace the lost skin or promote the regeneration of damaged skin. Skin regenerative biomaterials are highly applauded because they can exempt patients with severe burns from the painful procedure of autologous skin transplantation. Notwithstanding decades of research, biocompatible, degradable, and printable biomaterials that can effectively promote skin regeneration as a transplantation replacement in clinical use are still scarce. Here, we report one type of all-protein hydrogel material as the product of the enzymatic crosslinking reaction of gelatin and a recombinant type III collagen (rColIII) protein. Doping the rColIII protein in gelatin reduces the inflammatory response as an implant underneath the skin. The all-protein hydrogel can be bioprinted as scaffolds to support the growth and proliferation of 3T3 fibroblast cells. The hydrogel used as a wound dressing promotes wound healing in a rat model of skin damage, showing a faster and healthier recovery than the controls. The rColIII protein in the hydrogel has been shown to play a critical role in skin regeneration. Altogether, this work manifests the development of all-protein gelatin-rColIII hydrogel and demonstrates its use in wound healing. The gelatin-collagen hydrogel wound dressing thereby may become a promising treatment of severe wounds in the future.
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