CHAPTER 8. Almac: An Industrial Perspective of Ene Reductase (ERED) Biocatalysis

The asymmetric hydrogenation of α,β-unsaturated compounds using ene-reductase enzymes (primarily from the ‘Old Yellow Enzyme’ family of flavoproteins) is moving from an academic curiosity to a technology with potential industrial relevance. Continuing identification and reporting of ene-reductases with improved stability properties and higher turnover numbers will ensure their incorporation into industrial processes. This chapter highlights literature examples of bioreductions available to the modern practical chemist.