蛋白激酶B
医学
番红花苷
内科学
血管生成
PI3K/AKT/mTOR通路
内分泌学
糖尿病
糖尿病性心肌病
心肌保护
癌症研究
链脲佐菌素
药理学
作者
Hassan Dariushnejad,Mustafa Mohammadi,Vajihe Ghorbanzadeh
出处
期刊:Bratislavské lekárske listy
日期:2019-01-01
卷期号:119 (12): 757-761
被引量:3
摘要
signalling. Methods Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p., 35 mg/kg). Animals received crocin orally (50 mg/kg), voluntary exercise was performed alone or together with crocin for 8 weeks. Akt and ERK1/2 levels were measured by ELISA and CD31 was detected by immunohistochemistry. Results Akt and ERK1/2 levels in crocin and exercise groups were significantly higher than in diabetic group. Levels of Akt and ERK1/2 proteins and CD31 immunostaining were also significantly higher in crocin-voluntary exercise group in comparison to the other groups. Conclusion Our results revealed that treatments with crocin and voluntary exercise had synergistic effect on angiogenesis. Protective effects of these interventions are probably through the activation of Akt and ERK 1/2 signalling pathways in the heart of diabetic rats (Fig. 3, Ref. 40).
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