Facile One-Pot Synthesis of 1,3,5-Trisubstituted Pyrazoles from α,β-Enones

A practical and efficient one-pot synthesis of 1,3,5-trisubstituted pyrazoles from ${\alpha},{\beta}$ -enones and arylhydrazine hydrochlorides has been developed. The pyrazoles were formed via a tandem formation of the corresponding pyrazolines and an acid-catalyzed aerobic oxidation process.