纳米纤维素
双层
纳米纤维
聚合物
脚手架
材料科学
化学工程
组织工程
气凝胶
乙烯醇
纤维素
多孔性
高分子化学
纳米技术
复合材料
化学
膜
生物医学工程
工程类
医学
生物化学
作者
Robab Ghafari,Mehdi Jonoobi,Leila Mohammadi Amirabad,Kristiina Oksman,Ahmad Reza Taheri
标识
DOI:10.1016/j.ijbiomac.2019.06.104
摘要
The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementioned polymers. FE-SEM analysis indicated that the fabricated scaffolds had interconnected pores with two defined pore size in each layer of the bilayer scaffolds that can recapitulate the two layers of the dermis and epidermis of the skin. Lower concentration of polymers causes higher porosity with larger pore size and increased water uptake and decreased mechanical strength. FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking. The MTT assay showed that these nanofibrous scaffolds meet the requirement as a biocompatible material for skin repair. Here, for the first time, we fabricated bilayer scaffold using a novel one-step freeze-drying technique only by controlling the polymer concentration with spending less time and energy.
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