光热治疗
材料科学
表面改性
纳米颗粒
介孔二氧化硅
阿霉素
透明质酸
药物输送
光热效应
涂层
体内
纳米技术
生物医学工程
化学工程
介孔材料
化学
有机化学
化疗
催化作用
生物技术
外科
工程类
生物
医学
遗传学
作者
Jingjing Hu,Miao‐Deng Liu,Ying Chen,Fan Gao,Song Peng,Bo‐Ru Xie,Chu‐Xin Li,Xuan Zhang,Xian‐Zheng Zhang
出处
期刊:Biomaterials
[Elsevier]
日期:2019-07-01
卷期号:207: 76-88
被引量:84
标识
DOI:10.1016/j.biomaterials.2019.03.043
摘要
Various negative effects accompanying with the instability of bare liquid metal (LM) nanoparticles, including undesirable spontaneous coalescence, continuous photothermal performance deterioration and difficult multi-step functionalization, severely hinder its applications in biomedical area. In this study, we proposed a new concept of immobilized liquid metal nanoparticles based on a surface mesoporous silica coating strategy (LM@MSN). Strikingly, it was found that unsteady and vulnerable LM nanoparticles after immobilization exhibited enhanced stabilization and sustainable photothermal performance even with a long and repeated light irradiation in acidic environments. Moreover, integrating the properties of easy surface functionalization and high drug loading efficiency from silica shell, immobilized LM nanoparticle was further used for photothermal involved combinational therapy. The classical anticancer drug doxorubicin (DOX) was encapsulated in pores of silica shell and the hyaluronic acid (HA) was decorated on LM@MSN to construct LM@MSN/DOX@HA for tumor targeted combination therapy. Both in vitro and in vivo studies proved that LM@MSN/DOX@HA could significantly inhibit solid tumor growth under near infrared (NIR) irradiation by synergistic photothermal/chemotherapy.
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