Synthesis and Application of Monofluoroalkyl Building Blocks: α‐Halo‐α‐fluoroketones

Abstract A convenient and versatile synthesis of α‐halo‐α‐fluoroketones, including α‐iodo‐α‐fluoroketones, α‐bromo‐α‐fluoroketones and α‐chloro‐α‐fluoroketones by using Wu–Colby's protocol involving the release of trifluoroacetate was reported. The ketones’ application as monofluoroalkyl building blocks was explored through coupling and radical reactions. The results indicated that α‐iodo‐α‐fluoroketones are the most popular reagents to construct diverse valuable single‐fluorinated molecules.