孟德尔随机化
全国健康与营养检查调查
四分位数
氧化应激
医学
甲状腺功能
内科学
人口
贝叶斯多元线性回归
内分泌学
生理学
甲状腺
生物
遗传学
线性回归
环境卫生
基因型
统计
遗传变异
基因
数学
置信区间
作者
Liying Song,Haonan Zhou,Qian Yang,Nieburgs He,Feifan Fu,Weichao Li,Guosheng Duan,Di Wu,Shuai Hao,Jiaxing Wang,J.-T. Liu
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2024-03-18
卷期号:19 (3): e0298860-e0298860
标识
DOI:10.1371/journal.pone.0298860
摘要
Background Oxidative stress is a significant contributor to the development of various diseases, and the oxidative balance score (OBS) is a valuable tool for assessing the impact of dietary and lifestyle factors on oxidative stress in humans. Nevertheless, the precise relationship between OBS and thyroid function in adults remains elusive. Methods This cross-sectional study comprised 6222 adult participants drawn from the National Health and Nutrition Examination Survey (NHANES) conducted from 2007 to 2012. Employing weighted multivariable linear regression modeling, the study estimated the connection between OBS quartiles and thyroid functions. The causal relationship between OBS components and thyroid function was analyzed by Mendelian randomization (MR). Results We found a significant negative correlation between OBS and free thyroxine (FT4) and total thyroxine (TT4). Univariate and multivariate MR Analyses showed a causal relationship between BMI and FT4. Copper, smoking, and riboflavin showed a causal relationship with FT4 after moderation. Conclusion We found that a lifestyle high in antioxidant exposure reduced FT4 and TT4 levels in the population. We suggest that BMI, Copper, and Riboflavin are important factors in the regulation of FT4 levels.
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