真菌性角膜炎
抗真菌
角膜炎
角膜病
体内
生物相容性
化学
体外
抗真菌药
药品
微生物学
纳米技术
材料科学
角膜
生物
医学
药理学
眼科
生物化学
生物技术
冶金
作者
Huiying Chen,Xin-Peng Geng,Qian Ning,Liuqi Shi,Nan Zhang,Siyu He,Mengyang Zhao,Junjie Zhang,Zhanrong Li,Jun Shi,Jingguo Li
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-03-22
卷期号:24 (13): 4044-4053
被引量:1
标识
DOI:10.1021/acs.nanolett.4c01042
摘要
Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness of conventional antifungal drugs is limited due to the intrinsic ocular barrier that impedes drug absorption. There is an urgent need to develop new therapeutic strategies to effectively combat FK. Herein, we synthesized an ultrasmall positively charged carbon dot using a simple stage-melting method. The carbon dot can penetrate the corneal barrier by opening the tight junctions, allowing them to reach the lesion site and effectively kill the fungi. The results both in vitro and in vivo demonstrated that it exhibited good biocompatibility and antifungal activity, significantly improving the therapeutic effect in a mouse model of FK. Therefore, this biophilic ultrasmall size and positive carbon dot, characterized by its ability to penetrate the corneal barrier and its antifungal properties, may offer valuable insights into the design of effective ocular nanomedicines.
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