槲皮素
药理学
止痛药
对接(动物)
化学
医学
生物化学
抗氧化剂
护理部
作者
Amina Ettitaou,Hamid Kabdy,Khadija Oubella,Karima Raoui,Mehdi Oubahmane,Rachida Aboufatima,Loubna Elyazouli,Stefania Garzoli,Abderrahman Chait
标识
DOI:10.1080/14786419.2024.2333053
摘要
The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test. Additionally, evaluation of its anti-inflammatory activity showed a reduction in ear oedema. However, it is important to note that quercetin administration has not been shown to significantly reduce yeast-induced hyperthermia. The docking study revealed the high inhibitory potential of quercetin against the COX-2 receptor.
科研通智能强力驱动
Strongly Powered by AbleSci AI