自愈水凝胶
材料科学
明胶
3D生物打印
人脐静脉内皮细胞
复合数
壳聚糖
脐静脉
生物医学工程
纳米技术
化学工程
组织工程
复合材料
高分子化学
化学
医学
生物化学
体外
工程类
作者
Lei Wang,Anduo Zhou,Chongshuai Chen,Xia Huang,Shanfeng Zhang,Junying Chen
摘要
Abstract Bioprinted scaffolds have broad applications in the treatment of cardiovascular diseases. 3D bioprinting can prepare complex structures and shapes, and the fabrication of high‐performance bioinks is the key to technological progress. This study selected gelatin, chitosan quaternary ammonium salt, and sodium cromoglycate as substrates to design and characterize two groups of hydrogel materials for bioprinting. Two hydrogels were prepared by extrusion bioprinting: Gel/HACC/DSCG hydrogel and GelMA/HACC‐DSCG hydrogel. The physicochemical and liquid crystal properties of hydrogels were characterized. The effect of liquid crystal on cell proliferation and orientation was evaluated by culturing human umbilical vein endothelial cells. The Gel/HACC/DSCG hydrogels showed inducibility to orientated cell growth. The GelMA/HACC‐DSCG hydrogels had lesser damaged cells and stronger mechanical strength and stability in printing, however, the liquid crystal properties were weakened, and the effect on cell growth orientation was not significant.
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