四环素
废水
抗性(生态学)
抗生素耐药性
微生物学
环境科学
生物
环境工程
抗生素
生态学
作者
Howard Ochman,Erik M. Quandt,Neil Gottell,Jack A. Gilbert
摘要
Microbial communities serve as reservoirs of antibiotic resistance genes (ARGs) and facilitate the dissemination of these genes to bacteria that infect humans. Relatively little is known about the taxonomic distribution of bacteria harboring ARGs in these reservoirs and the avenues of transmission due to the technical hurdles associated with characterizing the contents of complex microbial populations and the assignment of genes to particular genomes. Focusing on the array of tetracycline resistance (Tcr) genes in the primary and secondary phases of wastewater treatment, 17 of the 22 assayed Tcr genes were detected in at least one sample. We then applied epicPCR to link tetracycline resistance genes to specific bacterial hosts. Whereas Tcr genes tend to vary in their distributions among bacterial taxa according to their modes of action, there were numerous instances in which a particular Tcr gene was associated with a host that was distantly related to all other bacteria bearing the same gene. Tcr genes are far less host-restricted than previously assumed, indicating that complex microbial communities serve as settings where ARGs can be transferred among divergent bacterial phyla.
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