色谱法
动物科学
显著性差异
防腐剂
化学
医学
分析化学(期刊)
内科学
生物
食品科学
作者
Cerin John,Carolyn Piggott,Sally C Benton
标识
DOI:10.1177/00045632231183850
摘要
Background: Faecal immunochemical tests (FIT) are routinely used in colorectal cancer (CRC) screening programmes around the world. More recently, quantitative FIT has been recommended to help triage patients presenting to primary care with symptoms suggestive of CRC. Participants collect faecal samples using sampling probes which are inserted into sample collection devices (SCDs) containing preservative buffer. The SCDs have an internal collar designed to remove excess sample. The aim of this study was to investigate the impact of multiple loading on faecal haemoglobin concentration (f-Hb) using SCDs of four FIT systems.
Methods: Pools of f-Hb negative samples were spiked with blood, homogenised and loaded into SCDs 1, 3 and 5 times, with insertion of the sampling probes into the SCDs with and without mixing between loads. The f-Hb was measured using the relevant FIT system. The percentage change in f-Hb for multiple loads were compared with a single load for each system for the mixed and unmixed groups.
Results: The p values show a significant difference (p<0.05) in the mass and f-Hb for the mixed and unmixed group, for 1-3 and 1-5 loads for all systems. The median percentage change in f-Hb for the mixed is higher than the unmixed group.
Conclusion: This study showed that multiple loading does significantly increase the f-Hb in the SCDs.
科研通智能强力驱动
Strongly Powered by AbleSci AI