点击化学
药物发现
化学
纳米技术
化学生物学
药物开发
组合化学
计算机科学
计算生物学
生化工程
药品
生物
生物化学
材料科学
药理学
工程类
作者
Ana Carolina Amorim Orrico,Anthony J. Burke
标识
DOI:10.1080/17460441.2024.2302151
摘要
Drug discovery and development has benefited enormously from the amazing advances that have been made in the field of click chemistry since 2001. The methods most likely to have the most future applications include metal-catalyzed azide-alkyne cycloadditions giving 1,2,3-triazoles, SPAAC for medical diagnostics and vaccine development, other congeners, Sulfur-Fluoride Exchange (SuFEx) and Diversity-Oriented Clicking (DOC), a concept with diverse molecular methodology with the potential for obtaining extensive molecular diversity.
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