Combination of YAP inhibition and photodynamic therapy induces dual DNA damage and activates STING pathway to enhance immunotherapy in uveal melanoma

) T-cell expansion, suppressed tumor growth by 96.20 ± 7.22 %, and extended survival from 33 to >80 days in orthotopic UM models. Importantly, rechallenge experiments confirmed durable antitumor immunity and prevention of UM recurrence. Overall, our findings established HANP/VP as a multifunctional nanomedicine that reprogrammed the TME and elicited potent antitumor immunity through dual DNA damage and STING activation. The study highlights a promising translational strategy for overcoming immunotherapeutic resistance in UM and converting immunologically "cold" tumors into "hot" ones, thereby improving responses to immune checkpoint blockade (ICB).